O-Desmethyltramadol (also known as O-DSMT and desmetramadol) is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol.[2]
O-DSMT has no documented history of human use before it appeared for sale on the research chemical market in the 2010s.
Subjective effects include sedation, pain relief, anxiety suppression, muscle relaxation, and euphoria. In comparison to tramadol, O-DSMT is reported to be less stimulating and feels considerably closer to a traditional opiate. Being the metabolite that is mainly responsible for the analgesic effect of tramadol, O-DSMT is significantly more potent by weight than its parent compound.
O-DSMT has a very short history of human use and not much is known about its toxicity and abuse potential. It is highly advised to use harm reduction practices if using this substance.
